Trans-10,cis-12, Not cis-9,trans-11, Conjugated Linoleic Acid Inhibits G1-S Progression in HT-29 Human Colon Cancer Cells
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چکیده
منابع مشابه
Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells.
Commercial preparations of conjugated linoleic acid (CLA) contain both positional and geometric isomers of octadecadienoic acid, with cis-9,trans-11 CLA (c9t11) and trans-10,cis-12 CLA (t10c12) as the principal isomers. We showed previously that CLA reduced the incidence of colon tumors in rats treated with 1,2-dimethylhydrazine. In addition, our previous in vitro studies showed that t10c12 inh...
متن کاملTrans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth.
A commercially available mixture of conjugated linoleic acid (CLA) isomers decreases colon cancer cell growth. We compared the individual potencies of the two main isomers in this mixture [cis-9,trans-11 (c9t11) and trans-10,cis-12 (t10c12)] and assessed whether decreased cell growth is related to changes in secretion of insulin-like growth factor II (IGF-II) and/or IGF-binding proteins (IGFBPs...
متن کاملTrans-10, cis-12 Conjugated Linoleic Acid
Conjugated linoleic acids (CLA) are a group of linoleic acid isomers having double bonds in conjugated position, i. e. the double bonds are separated by one single bond. Two of the isomers: cis-9, trans-11 (c9, t11) and trans-10, cis-12 (t10, c12) CLA, have been shown to have biologically interesting properties. The c9, t11 CLA has been reported to have anticancer, antidiabetic and anti-inflamm...
متن کاملConjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line.
Conjugated linoleic acid (CLA) has chemoprotective properties in experimental cancer models, and in vitro studies have shown that CLA inhibits HT-29 colon cancer cell growth. ErbB2 and ErbB3 have been implicated in the development of colon cancer, and both proteins are expressed at high levels in the HT-29 cell line. Activation of ErbB2/ErbB3 heterodimers is regulated by the ErbB3 ligand heregu...
متن کاملATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells
Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to the ATF/CREB family of transcription factors and is associated with apoptosis in colorectal cancer. The present study was performed to investigate the molecular mechanism by which t10, c12-CLA stim...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2006
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/136.4.893